KMID : 1161420180210030261
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Journal of Medicinal Food 2018 Volume.21 No. 3 p.261 ~ p.268
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Echinacea purpurea Protects Against Restraint Stress-Induced Immunosuppression in BALB/c Mice
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Park Seon-Young
Lee Mak-Soon Jung Sun-Yoon Lee Seo-Hyun Kwon O-Ran Kreuter Matthias Heinrich Perrinjaquet-Moccetti Tania Min Bok-Kee Yun Seong-Ho Kim Yang-Ha
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Abstract
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Echinacea purpurea has been widely used for the prevention and treatment of upper respiratory tract infections and the common cold. The restraint stress has been reported to suppress a broad spectrum of immune functions. The aim of this study was to investigate the protective effects of the pressed juice of E. purpurea (L.) Moench (EFLA¢ç894; Echinacea) against restraint stress-induced immunosuppression in BALB/c mice. Echinacea significantly normalized the restraint stress-induced reduction in splenocyte proliferation and splenic natural killer (NK) cell activity (P?.05). Echinacea treatment significantly increased the percentages of CD4+ and CD8+ T lymphocytes in the blood (P?.05). In addition, Echinacea restored serum cytokine levels, including interleukin-6 (IL-6), interleukin-10 (IL-10), and interleukin-17 (IL-17), as well as the mRNA expressions of these cytokines in spleen (P?.05). Our findings suggest that Echinacea might have beneficial effects on restraint stress-induced immunosuppression by increasing splenocyte proliferation and NK cell activity, while modulating T lymphocyte subsets and cytokine levels in the blood.
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KEYWORD
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cytokines, Echinacea purpurea, immune, NK cell, restraint stress, T lymphocyte
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